Scientific considerations and ethical constraints have driven a worldwide shift towards human health safety assessment of chemicals without the use of animal testing. This modern ‘Next Generation Risk Assessment’ (NGRA) approach is exposure-led and hypothesis driven, and relies on the integration of non-animal data derived from in silico, in chemico and in vitro methodologies (i.e. New Approach Methodologies or NAMs). This paradigm shift opens new opportunities for computational approaches and artificial intelligence in the field of chemical risk assessment.
The way forward for assessing the human health safety of cosmetics in the EU - Workshop proceedings.
Numerous research projects of IVTD fall under this approach:
- The use of adverse outcome pathways in the safety evaluation of food additives. Project led by Mathieu Vinken
- Non-Animal Methodologies for Toxicity Testing of Chemical Compounds (TOXIN). Project led by Tamara Vanhaecke
- “Next Generation Risk Assessment” (NGRA) to assess the genotoxicity of chemical compounds without the use of experimental animals. Project led by Tamara Vanhaecke, Vera Rogiers and Birgit Mertens