EXPERTISE

TOXICOLOGY, LIVER CELL BIOLOGY & PATHOLOGY RESEARCH

Development and validation of human relevant in vitro liver models for:
- Hepatotoxicity screening and Drug Induced Liver Injury (DILI) prediction
- In vitro non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) modelling and drug target discovery
- Innovative culture systems towards lab-on-chip applications
Novel gene therapies approaches for inherited metabolic disorders (IMD) of the liver
Targeting liver cell signalling in the treatment of liver disease

Promotion alternative methodologies through the Innovation Centre-3Rs (IC-3Rs)
Centralization of New Approach Methodologies (NAMs) for the Flemish and Brussels regions in one central database (RE-PLACE)

Advancing the next generation risk assessment (NGRA) methods
Developing new analytical methods for the identification of harmful ingredients towards consumer safety, in collaboration with Sciensano

Flow cytometry-based high throughput screening of various hepatic cell models, for live/dead cell analysis, lipid and phospholipid accumulation
Microscopy-based high content analysis for lipid and mitochondrial deregulation analysis
Genotoxicant-specific qPCR array
Transcriptomics and metabolomics readouts and analysis

Providing regulatory and industry-orientated training in safety and efficacy of dermato-cosmetics
Pharmacy education of future pharmaceutical industry professionals and community pharmacists
Consultancy services based on expertise in in vitro experimental toxicology, stem cell technologies as well as safety and efficacy evaluation of cosmetic ingredients