TOXIN: Non-Animal Methodologies for Toxicity Testing of Chemical Compounds
Currently, there are no validated animal-free replacement methods to assess repeated dose toxicity. This poses serious problems for the development of new chemical compounds across a variety of sectors, in particular cosmetics, where animal use is now fully banned in the EU. Advancing safety assessment of chemicals without the use of animal testing is thus urgently required to ensure a level of safety that is at least equivalent to that obtained through animal testing.
The goal of this IRP is to establish non-animal based, human-relevant strategies to assess repeated dose toxicity. This will be achieved through the unique combination of expertise in in vitro experimental toxicology (IVTD), computational information systems (WISE), and ethics and legislation (LSTS).
The objectives are:
This approach can be extrapolated to any other organ and/or type of chemical and will trigger follow-up initiatives across diverse industrial sectors, ensuring continuity of the IRP.