IVTD’s patented human skin stem cell-derived hepatic cell model (hSKP-HPC or HepaSTARs) provides a sensitive and accurate assay for toxicity screening of novel drug candidates and the detection of drug-induced steatosis, phospholipidosis and acute liver failure, and has been tested using compounds with known toxicity, including sodium valproate and paracetamol. The hSKP-HPC model compares favourably with human hepatocytes, HepG2 and HepaRG™ cells in assessing hepatotoxicty.
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led by Tamara Vanhaecke